A rapid solid supported synthesis of 4-amino-5-(pyridin-4-YL)-4H-1,2,4-triazol-3- thiol and its derivatives

Shahana Ehsan, Sahar Sarfraz, Bushra Khan, Syeda Mona Hassan and Munawar Iqbal

Abstract

1,2,4-triazoles and its substituted derivatives were synthesized since these compounds are known for their excellent antibacterial, antifungal, antitubercular, antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant and anxiolytic activities. 1,2,4-triazole and substituted derivatives of 1,2,4- triazole were synthesized using solid state microwave irradiation technique and synthesized compounds were characterized by UV-Visible, FTIR and GC-MS techniques and in future study the biological activities of synthesized compounds will be studied.