Kinetic and thermodynamic properties of pharmaceutical drug (Gabapentin) by potassium bromate (KBrO3) in presence of micro amount of Ir(III) chloride as catalyst in acidic medium

Reena Patel, Shailesh Kumar, Abhishek Verma and Sheila Srivastava

Abstract

The kinetic and thermodynamic properties of pharmaceutical drug (gabapentine) by potassium bromate (KBrO3) in presence of Micro amount of Ir(III) chloride as catalyst in acidic medium was studied in the temperature range 30 to 45 0C. The
reaction is carried out in the presence of mercuric acetate as a scavenger for chloride ion. 1-carboxy cyclohexane l-acetic acid was obtained as the oxidation product and identified chromatographically. The rate law followed a first order
and zero order dependence with respect to KBrO3 and GBP respectively. The reaction followed first order with respect to Ir(III) chloride and [H+]. Negligible effect of [Hg(OAc)2] and ionic strength of the medium was observed. Chloride ion
positively influenced the rate of reaction. The values of rate constants observed at different temperatures (30 to 45 0C) were utilized to calculate the activation parameters. Feasible mechanism is proposed which are composed with the
kinetics, stochiometry and product of the reaction. The rate law has been derived from obtained kinetic data.