Chemical constituents, antimicrobial and antioxidant properties of the aerial parts of Coccinia barteri

Abdulmumeen A. Hamid , Stephen O. Oguntoye, Abdulrahaman A. Mukadam, Abdulgafar O. Zubair, Emmanuel O. Fagbohun, Joshua Adeyemo, Muinat A. Aliyu, Joseph B. Ojo and Bashir Olaniyi

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Phytochemical analysis of n-hexane, ethyl acetate and methanol extracts of the aerial parts of Coccinia barteri was carried out. These extracts exhibited satisfactory inhibitory activities against bacteria and fungi strains, which include;
Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Salmonella typhii, Klebsiella pneumoniae, Candida albicans, Aspergillus niger, Penicillium notatum and Rhizopus stolonifer. Methanol extract of C. barteri
possesses antioxidant activity by scavenging DPPH free radical with IC50 of 187.56 µg/mL, using DPPH antioxidant assay. GC-MS analysis of n-hexane, ethyl acetate and methanol extracts of the plant principally revealed the presence of
phytol, ethyl hexadecanoate and clionasterol with their corresponding percentage abundance of 57.75%, 18.33% and 9.79%, respectively.