Issue 2

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Asif, M., 2015. The impact of dietary fat and polyunsaturated fatty acids on chronic renal diseases. Current Science Perspectives 1(2), 51 -61


Thestudies suggest an association between polyunsaturated fatty acids (PUFAs) and the development of chronic kidney disease. Study the relationship between PUFAs and renal function in older adults. Dietary modification is an important component of the medical management of chronic renal failure (CRF) in dogs. The objectives are1: to meet the patient’s nutrient and energy requirements to alleviate clinical signs of uremia through reduction of protein catabolites, to minimize electrolyte, vitamin, and mineral disturbances, to slow progression of renal failure. People with higher creatinine clearance had higher concentrations of HDL cholesterol, total plasma PUFAs, plasma n-3 FA, and plasma n-6 FA and lower triglycerides. Baseline total plasma PUFAs, n-3 FA, n-6 FA, and linoleic, linolenic, and arachidonic acids were strong independent predictors of less steep decline in creatinine clearance from baseline, after adjusting for baseline creatinine clearance). After adjusting for baseline creatinine, baseline total plasma PUFAs, n-3 FA, and linoleic, linolenic, and arachidonic acids were negatively associated with creatinine at 3-year follow-up. People with higher plasma PUFAs at enrollment had a lower risk of developing renal insufficiency.


Padmavathy, S., Asha Devi, N.K., Alagar, M., Dinesh Babu, R., 2015. Characterization and antibiogram pattern of marine bacteria against multi drug resistant pathogens. Current Science Perspectives 1(2), 62-68


Over the past decade, marine microbes have been recognized as an untapped resource for novel bioactive compounds. To facilitate this avenue of research, fifty one bacterial strains were isolated from five different coastal locations in Gulf of Mannar region. All the isolates were subjected to primary screening against 17 test organisms. Ten bacterial isolates showed antagonistic activity varied from 14 to 20 mm against the entire gram positive, gram negative and fungal test pathogens. In secondary screening, five bacterial strains numbered as MB7, MB16, MB24, MB34 and MB44 showed antagonistic activity to all the selected test organisms. Selected five bacterial strains MB7, MB16, MB24, MB34 and MB44 were identified as Marinonascens sp., Bacillus sp., Mesophilobacter sp., Alteromonas sp., Marinococcus sp., respectively. From the optimization studies, it was found that the bacterial supernatants obtained at 37°C, pH 7and 3% NaCl concentration showed broad spectrum activity against all the indicator test organisms. But the bacterial strain Bacillus sp., spore producing organism showed equally effective antimicrobial activity against all the target multi drug resistant pathogens at pH 8 and 9, and NaCl concentration at 5% and 7% NaCl in  optimization studies. Chemical characterization using FTIR spectrum analysis, showed that the compound may probably having one hydroxyl methyl group, primary or secondary amines or amides and –CH-OH (hydroxyl methylenes) are linked to each other by ether linkages. In the spectral analysis for MB16 containing peaks for complex rings. Thus the antimicrobial compound probably is a straight chain polyhydroxy polyether compound with a single double bond possessing complex ring structure. It indicated that these metabolites can be used as potential bioactive products. In conclusion, it can be stated that the marine bacteria still acting as a prolific source for producing bioactive metabolites in controlling human disease causing pathogens.



Mensah, J.K., Golomeke, D., 2015. Antioxidant and antimicrobial activities of the extracts of the Calyx of Hibiscus Sabdariffa Linn. Current Science Perspectives 1(2), 69-76


The calyces of Hibiscus sabdariffa Linn are widely used for nutritional and medicinal purposes in Ghana. This study assessed the antioxidant and antimicrobial activities of the aqueous and the ethanol (hydro-ethanol) extracts (30%) of the calyces of H. sabdariffa Linn. The hydro-ethanol extract exhibited a more potent antioxidant potential versus aqueous extract as demonstrated by its higher Total Antioxidant Capacity (TAC) and its lower EC50 for both the DPPH and the Hydroxyl radical scavenging activities. Additionally, the hydro-ethanolic extract displayed more potent antimicrobial activities with larger zones of inhibition in the agar diffusion assay and lower MICs in the broth dilution assay against a set of microorganisms including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans. The data supports the ethnomedicinal use of the aqueous infusion of H. sabdariffa Linn for the management of urinary tract infections and other symptoms that may be linked to oxidative stress.