Single crystal synthesis and structure of 2-phenyl-1-(4-phenylacetyl-piperazin-1-yl) ethanone and antimalarial potential evaluation

A. Ocheni, P.O. Ukoha and E. Hosten

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In the present investigation, 2-phenyl-1-(4-phenylacetyl-piperazin-1-yl) ethanone was prepared and antimalarial activity was also evaluated. The reactions of phenylacetyl chloride and piperazine in trichloromethane at 60 0C affording a dione, 2-Phenyl-1-(4-Phenylacetyl-piperazin-1-yl)ethanone (L) furnished a good yield. This compound was characterized by melting point determination, solubility, UV-Vis, FTIR and nuclear magnetic resonance spectroscopy. The crystal structure was confirmed and established by X-ray Crystallography. The afforded dione with molecular weight 322.40 crystallizes in monoclinic space group with lattice type p 21/n with a = 8.227(5), b = 11.689(6), c = 8.9954(5) A0,­ α = 90, β = 102.280(2), γ = 900 and z = 2. Investigation of the antimalarial potential of this compound revealed the effects of sample on parasthemia count of mice infected with plasmodium berghie is dose dependent with 250 mg/kg showing 51.09% and 500 mg/kg having 65.91%.  LD50 results of the compound show high effective dose since no mortality of mice was recorded even at high dose.