Antibacterial and antioxidant activity of p-quinone methide derivative synthesized from 2,6-di-tert-butylphenol

Ibrahim Muhammad1, Srirekha Pandian and Waheeta Hopper

Abstract

Quinone methides and its derivatives have recently gained much attention as the potential building block of some important drugs in medicinal chemistry. Herein, 2,6-di-tert-butyl-4-(4-methoxybenzylidene)cyclohexa-2,5-dienone was prepared
from 2,6-di-tert-butylphenol, which was characterized and antibacterial and antioxidant activities were evaluated. The as-synthesized compound exhibited good antioxidant and antibacterial activity against selected test organisms with zone of inhibition ranging between 7 mm to 9 mm at concentration of 2.5, 5.0, and 7.5 (mg/mL), respectively. The result shows that the compound may be a potential candidate of reducing human suffering from bacterial infections since antibacterial activity was promising.